Kilmartin performed stand-up on CONAN, Jimmy Kimmel Live!, Comedy Central's Premium Blend, Showtime, the USO Tour Cuba, performing for troops in Iraq, Shorties Watchin' Shorties, Verdict with Dan Abrams, Red Eye with Greg Gutfeld, and The World Stands Up. She has been featured at comedy festivals in Aspen, Edinburgh, and Montreal.
Laurie Kilmartin also appeared on VH1 Best Week Ever, The Today Show, White Boyz in Da Hood, Countdown with Keith Olbermann, The Rachel Maddow Show, Fox & Friends, and The Oprah Winfrey Show.
Her comedy special, 45 Jokes About My Dead Dad, stand up comedy about cancer, hospice, death, grieving and funerals, debuted on Seeso, Dec 29th 2016.
Kilmartin was also a Top Ten finalist in season 7 of NBC's Last Comic Standing. She was also listed in The Huffington Post 53 Favorite Female Comedians list in 2011.
As a writer, Kilmartin was on the staff of The Late Late Show, Tough Crowd with Colin Quinn (on which she was also a frequent panelist), and Comedy Central's Too Late with Adam Carolla and The Bonnie Hunt Show. She also wrote articles published on Huffington Post, Babble.com, and co-authored Sherri Shepherd's memoir, Permission Slips.
In 2012, she wrote the New York Times bestseller Shitty Mom. Kilmartin is a single mother who often jokes about her son and motherhood.